How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
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#56 Polygenic risk scores in admixed populations with Bárbara Bitarello
Manage episode 285200844 series 1537951
Contenido proporcionado por Roman Cheplyaka. Todo el contenido del podcast, incluidos episodios, gráficos y descripciones de podcast, lo carga y proporciona directamente Roman Cheplyaka o su socio de plataforma de podcast. Si cree que alguien está utilizando su trabajo protegido por derechos de autor sin su permiso, puede seguir el proceso descrito aquí https://es.player.fm/legal.
Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS) to predict the phenotype based on the genotype. However, the prediction accuracy suffers when GWAS from one population are used to calculate PRS within a different population, which is a problem because the majority of the GWAS are done on cohorts of European ancestry.
In this episode, Bárbara Bitarello helps us understand how PRS work and why they don’t transfer well across populations.
Links:
- Polygenic Scores for Height in Admixed Populations (Bárbara D. Bitarello, Iain Mathieson)
- What is ancestry? (Iain Mathieson, Aylwyn Scally)
If you enjoyed this episode, please consider supporting the podcast on Patreon.
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Manage episode 285200844 series 1537951
Contenido proporcionado por Roman Cheplyaka. Todo el contenido del podcast, incluidos episodios, gráficos y descripciones de podcast, lo carga y proporciona directamente Roman Cheplyaka o su socio de plataforma de podcast. Si cree que alguien está utilizando su trabajo protegido por derechos de autor sin su permiso, puede seguir el proceso descrito aquí https://es.player.fm/legal.
Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS) to predict the phenotype based on the genotype. However, the prediction accuracy suffers when GWAS from one population are used to calculate PRS within a different population, which is a problem because the majority of the GWAS are done on cohorts of European ancestry.
In this episode, Bárbara Bitarello helps us understand how PRS work and why they don’t transfer well across populations.
Links:
- Polygenic Scores for Height in Admixed Populations (Bárbara D. Bitarello, Iain Mathieson)
- What is ancestry? (Iain Mathieson, Aylwyn Scally)
If you enjoyed this episode, please consider supporting the podcast on Patreon.
70 episodios
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Similar a the bioinformatics chat
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
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…
continue reading
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…
continue reading
This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
…
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…
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…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
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continue reading
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