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EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of Human Genetics at UCSF
MP3•Episodio en casa
Manage episode 440731182 series 2631947
Contenido proporcionado por Sano Genetics. Todo el contenido del podcast, incluidos episodios, gráficos y descripciones de podcast, lo carga y proporciona directamente Sano Genetics o su socio de plataforma de podcast. Si cree que alguien está utilizando su trabajo protegido por derechos de autor sin su permiso, puede seguir el proceso descrito aquí https://es.player.fm/legal.
01:15 - Introductions
02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career
04:56 - Our current understanding of non-coding genome grammar
07:40 - Is there a missing piece to the common variant, common disease paradigm?
10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)
12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?
14:25 - The potential of machine learning
16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases
20:19 - Nadav’s experience of starting a company
24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing
26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?
34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels
38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans
40:33 - Closing remarks
181 episodios
MP3•Episodio en casa
Manage episode 440731182 series 2631947
Contenido proporcionado por Sano Genetics. Todo el contenido del podcast, incluidos episodios, gráficos y descripciones de podcast, lo carga y proporciona directamente Sano Genetics o su socio de plataforma de podcast. Si cree que alguien está utilizando su trabajo protegido por derechos de autor sin su permiso, puede seguir el proceso descrito aquí https://es.player.fm/legal.
01:15 - Introductions
02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career
04:56 - Our current understanding of non-coding genome grammar
07:40 - Is there a missing piece to the common variant, common disease paradigm?
10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)
12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?
14:25 - The potential of machine learning
16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases
20:19 - Nadav’s experience of starting a company
24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing
26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?
34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels
38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans
40:33 - Closing remarks
181 episodios
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