How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens
MP3•Episodio en casa
Manage episode 413195222 series 2631947
Contenido proporcionado por Sano Genetics. Todo el contenido del podcast, incluidos episodios, gráficos y descripciones de podcast, lo carga y proporciona directamente Sano Genetics o su socio de plataforma de podcast. Si cree que alguien está utilizando su trabajo protegido por derechos de autor sin su permiso, puede seguir el proceso descrito aquí https://es.player.fm/legal.
0:00 Intro
0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science
5:30 Opportunities for research and drug development in the realm of somatic science
9:20 Somatic evolution and how it provides valuable insights into disease mechanisms
12:30 Advantages and disadvantages of studying germline genome-wide association studies (GWAS) versus somatic genomes for target and drug discovery
17:00 How germline and somatic mutations can complement one another when studying conditions like MASH, autoimmune disorders, infectious diseases, and more
21:10 The method behind obtaining and analysing tissue samples
24:00 The importance of high resolution for somatic variation
29:30 “The genetics superhero”: How somatic variations can rescue maladaptive germline mutations
32:00 How to obtain tissue samples of hard-to-reach areas of the body, like the brain
33:00 How somatic genome can increase the scale of DNA data available
36:00 Best practices for scientific entrepreneurship
44:50 Jake’s predictions for the next big breakthroughs in genetics and precision medicine
48:20 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
170 episodios
MP3•Episodio en casa
Manage episode 413195222 series 2631947
Contenido proporcionado por Sano Genetics. Todo el contenido del podcast, incluidos episodios, gráficos y descripciones de podcast, lo carga y proporciona directamente Sano Genetics o su socio de plataforma de podcast. Si cree que alguien está utilizando su trabajo protegido por derechos de autor sin su permiso, puede seguir el proceso descrito aquí https://es.player.fm/legal.
0:00 Intro
0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science
5:30 Opportunities for research and drug development in the realm of somatic science
9:20 Somatic evolution and how it provides valuable insights into disease mechanisms
12:30 Advantages and disadvantages of studying germline genome-wide association studies (GWAS) versus somatic genomes for target and drug discovery
17:00 How germline and somatic mutations can complement one another when studying conditions like MASH, autoimmune disorders, infectious diseases, and more
21:10 The method behind obtaining and analysing tissue samples
24:00 The importance of high resolution for somatic variation
29:30 “The genetics superhero”: How somatic variations can rescue maladaptive germline mutations
32:00 How to obtain tissue samples of hard-to-reach areas of the body, like the brain
33:00 How somatic genome can increase the scale of DNA data available
36:00 Best practices for scientific entrepreneurship
44:50 Jake’s predictions for the next big breakthroughs in genetics and precision medicine
48:20 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
170 episodios
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