August 2022: Subcortical Brain Development in Autism and Fragile X Syndrome


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Dr. Mark D. Shen (University of North Carolina, Chapel Hill) discusses the trajectory of brain development in infants at risk for autism spectrum disorder (ASD) and fragile X syndrome. Longitudinal imaging was captured from 6 to 24 months to see how brain development differed between groups, and the development of the amygdala in infants at risk for ASD prior to onset of social deficits and clinical diagnosis.

  • Shen interview [01:03]
  • Why look at patients with potential ASD diagnosis in conjunction with fragile X syndrome patients? [04:20]
  • Why are differences in brain structure important? [05:46]
  • What’s the advantage of earlier diagnosis of ASD? [08:16]
  • What’s next for your research? [09:48]
  • Kalin interview [11:47]
  • Shen et al. [12:09]
  • Girault et al. [15:30]
  • Gerlach et al. [19:13]
  • Mosholder et al. [22:12]
  • Summary [25:31]

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