Los mejores podcasts de Prostatectomy (2024)

1
Lessons from ACDC-RP Trial: Designing Neoadjuvant Therapy Trials for Prostatectomy 3:07

10d ago3:07

3:07

Oncotarget #published this #editorial on September 30, 2024, in Volume 15, entitled “Lessons from the ACDC-RP trial: Clinical trial design for radical prostatectomy neoadjuvant therapy trials” by Rashid K. Sayyid and Neil E. Fleshner from the Division of Urologic Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Can…

1
Molecular Chaperones: Guardians of Tumor Suppressor Stability 3:01

1d ago3:01

3:01

BUFFALO, NY- October 16, 2024 – A new #review was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.”As highlighted in the abstract of this paper, "tumor suppressor" describes a diverse set of genes typically involved in suppressing metastasis, but which ca…

1
TP53 Mutated AML: Transplant or No Transplant 3:49

6d ago3:49

3:49

BUFFALO, NY- October 11, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Transplant or no transplant for TP53 mutated AML.”As highlighted in this editorial, TP53 mutations (mut) occur in 10–15% of acute myeloid leukemia (AML) cases, commonly associated with therapy-related AML (t-AML) and complex cyto…

1
Targeting Stem Cell-like Traits: How miR-10b Inhibition Treats Metastatic Breast Cancer 6:01

6d ago6:01

6:01

While there have been significant improvements in breast cancer detection and treatment, the outlook for metastatic breast cancer remains bleak, with only a 30% five-year survival rate. This is largely due to existing therapies’ inability to effectively target the unique characteristics of metastatic cells. One key factor in metastasis is miR-10b, …

1
Ten Years of ENZAMET | the gift that keeps on giving! 40:48

7d ago40:48

40:48

Today we celebrate one of our favourite clinical trials - ENZAMET! It is 10 years since ENZAMET opened and beyond its pivotal data establishing that adding enzalutamide to ADT improves survival for mHSPC patients, it continues to produce a very strong stream of high-quality findings that affect our practice today. ENZAMET also straddled an epochal …

1
Zika Virus as a Treatment for Brain Cancer: A Systematic Review 3:28

9d ago3:28

3:28

BUFFALO, NY- October 9, 2024 – A new #review was #published in Oncotarget's Volume 15 on September 30, 2024, entitled, “Zika virus and brain cancer: Can Zika be an effective treatment for brain cancer? A systematic review.”As highlighted in the introduction of this review, many studies have identified oncolytic viruses as a promising new class of t…

1
All your GU Highlights from #ESMO24! 54:00

11d ago54:00

54:00

Ask anyone which big oncology meeting gave us the best GU oncology highlights this year and the answer is easy! ESMO24 in Barcelona! Jammed full of key papers and so many highlights, Declan and Renu bring you a great overview in this GU Cast Conference Highlights from ESMO24. Listen to discussions with investigators and key opinion leaders, intervi…

1
GU Cast vs The Penis Project! With Melissa Hadley-Barrett 26:45

23d ago26:45

26:45

Penis Project is one of our favourite podcasts (and certainly popular with our patients), so we were delighted to welcome Host and Sexologist, Melissa Hadley-Barrett to join us for a chat. What is the Penis Project? Who is it for? (anyone with a penis, anyone who knows someone with a penis, or anyone who would like to have a penis apparently)! A cr…

1
Spectacular live robotic surgery at #ERUS24 in Bordeaux 1:05:13

26d ago1:05:13

1:05:13

The world's longest running live robotic surgery meeting took place in Bordeaux last week and Declan and Renu were there to bring you all the highlights! The 21st Meeting of the EAU Robotic Urology Section (ERUS) was their biggest ever with more than 1000 delegates watching more than 40 live surgeries from the world's top robotic surgeons. And this…

1
LuPSMA moves UpFront | first RCT data with Arun Azad and Michael Hofman 34:38

1M ago34:38

34:38

A big day at ESMO in Barcelona today as our friend and colleague A/Professor Arun Azad presents the results of the UpFront PSMA trial for the first time. The data were revealed in the main prostate cancer session at ESMO and simultaneously published in Lancet Oncology. UpFront PSMA is a randomised controlled trial comparing ADT and docetaxel, with …

1
Salvage Robotic Radical Prostatectomy | 500 cases later with Paul Cathcart 30:52

1M ago30:52

30:52

More than 500 salvage radical prostatectomies!!! Yep it would be fair enough to describe Dr Paul Cathcart as being "experienced" in the most challenging scenario we face as prostate cancer surgeons. Surgery for cancer recurrence in the prostate following radiotherapy or various forms of ablative therapy is never easy, and can all too often lead to …

1
#110: Getting My Mojo Back! 22:00

1M ago22:00

22:00

Mark shares his experience with recurrent prostate cancer and his journey through radiation treatment. He discusses the use of ADT medication to reduce testosterone levels before radiation, the side effects of ADT, the process of radiation treatment, and the emotional journey of completing treatment. Mark also talks about the importance of early de…

1
Three Big Waves in Testis Cancer | With Rob Hamilton and Ben Tran 26:14

2M ago26:14

26:14

Testis cancer! We don't talk enough about this on GU Cast. But we are making up for it today with a cracking overview of three hot topics in testis cancer a couple of world-leading testis cancer experts. We are joined by Rob Hamilton (Urologist, Princess Margaret Cancer Centre, Toronto), and Ben Tran (Medical Oncologist, Peter Mac, Melbourne) to di…

1
Why you should go to Bali!! | #UAA24 7:10

2M ago7:10

7:10

As if any of us need an excuse to go to beautiful Bali! Well the Urological Association of Asia (UAA) Annual Meeting takes place there from 5-8th September 2024. Renu caught up with Dr Agus Rizal Hamid recently to hear what the UAA have in store for us! www.uaa2024.comPor Professor Declan Murphy & Dr Renu Eapen

1
Key Roles of MIF, DDT, and CD74 in Melanoma Prognosis and Therapy 4:02

2M ago4:02

4:02

Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression in various cancers. Recent evidence suggests that MIF could be a therapeutic target in immune checkpoint inhibition (ICI) resistant melanomas; however, clinical evidence for MIF, and particularly for DDT, …

1
miR-10b Inhibition: A Strategy for Treating Metastatic Breast Cancer 2:41

2M ago2:41

2:41

BUFFALO, NY- August 28, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 26, 2024, entitled, “Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties.”As stated within the Abstract of the paper, despite advances in breast cancer screening and treatment, the prognosis for metastatic…

1
PSA and Testosterone | Why low numbers matter 20:37

2M ago20:37

20:37

How often do you check PSA and testosterone in your patients on androgen deprivation therapy? Probably not often enough!! Declan caught up with friend of the podcast Professor Axel Merseburger at a conference recently to chat about this under-appreciated topic. Don't get too distracted by fancy scans and genomic testing; but do make sure you know a…

1
Artificial Intelligence: Revolutionizing Precision Oncology 2:21

2M ago2:21

2:21

BUFFALO, NY- August 27, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on August 26, 2024, entitled, “Artificial intelligence: A transformative tool in precision oncology.”Artificial intelligence (AI) is revolutionizing society and healthcare, opening new possibilities for precision medicine. In oncology, immunotherapy (IO) has si…

1
Genotype Matters: Tailored Screening for Germline CHEK2 Variants 2:45

2M ago2:45

2:45

BUFFALO, NY- August 26, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on July 10, 2024, entitled, “Genotype matters: Personalized screening recommendations for germline CHEK2 variants.”Recognized as a moderate-risk gene, CHEK2—responsible for encoding the CHK2 protein, which plays a crucial role in the repair of DNA double-strand…

1
Disrupting NKG2A:HLA-E Interactions for Enhanced Anti-Cancer Immunity 2:39

2M ago2:39

2:39

BUFFALO, NY- August 21, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on July 17, 2024, entitled, “Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity.”Two studies using CRISPR screens in cancer cells identified HLA-E as a critical negative regulator of NK cell interactions with cancer cells. Consiste…

1
Role of the Gut Barrier in Colorectal Cancer Treatment 2:42

2M ago2:42

2:42

BUFFALO, NY- August 19, 2024 – A new #review was #published in Oncotarget's Volume 15 on August 14, 2024, entitled, “The gut barrier as a gatekeeper in colorectal cancer treatment.”Colorectal cancer (CRC) is highly prevalent and a major cause of cancer-related deaths worldwide. The primary curative treatment for CRC is surgical resection of the aff…

1
Remembering Dr Brian Kelly 1:30:47

2M ago1:30:47

1:30:47

Today we dedicate our podcast to the memory of our colleague, Dr Brian Kelly (40), who passed away unexpectedly this week. We are devastated to lose Brian, who was a Consultant Urologist at Peter Mac and Eastern Health here in Melbourne, and one of our closest friends in the world. Here we replay the Memorial Session which we conducted at Peter Mac…

1
Nanobody Inhibits Metastasis of Breast Tumor Cells to Lung in Mice 2:53

2M ago2:53

2:53

BUFFALO, NY- August 15, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 14, 2024, entitled, “A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice.”The vacuolar H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to control the pH of intracellular …

1
Response of BRAF-Mutated Spindle Cell Sarcoma to BRAF/MEK Inhibitors 2:48

2M ago2:48

2:48

BUFFALO, NY- August 14, 2024 – A new #casereport was #published in Oncotarget's Volume 15 on July 17, 2024, entitled, “Rapid but nondurable response of a BRAF exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors.”As noted in the introduction of the Abstract, the BRAF V600E substitution predicts a cancer's sensitiv…

1
New Directions in Targeting the Multifaceted BRAF in Cancer 2:28

2M ago2:28

2:28

BUFFALO, NY- August 12, 2024 – A new research perspective was published in Oncotarget's Volume 15 on July 16, 2024, entitled, “Targeting the multifaceted BRAF in cancer: New directions.”In cancer patients, BRAF-targeting precision therapeutics are effective against Class I BRAF alterations (p.V600 hotspot mutations) in tumors such as melanoma, thyr…

1
Combining Regorafenib and TAS102 to Target Gastrointestinal Cancers and Overcome Cancer Stemness 4:01

2M ago4:01

4:01

In this research paper, researchers demonstrate a promising new treatment option for refractory metastatic gastrointestinal cancers using a combination of two FDA-approved drugs.Researchers Jun Zhang, Lanlan Zhou, Shuai Zhao, and Wafik S. El-Deiry from Fox Chase Cancer Center and Brown University explore the potential of combining TAS102 (triflurid…

1
Three big things in advanced/high risk kidney cancer | With Rana McKay and Lewis Au 38:20

2M ago38:20

38:20

We were very happy to have world-famous kidney cancer guru Dr Rana McKay in Australia this week to do some educational events and to visit us at Peter Mac. So of course we also invited her to the GU Cast studio to pick her brains on all things kidney cancer, along with Dr Lewis Au, GU Medical Oncologist at Peter Mac. We asked them to cover three ho…

1
TCR CDR3s and Renalase-1 Linked to Increased Melanoma Survival 2:31

2M ago2:31

2:31

BUFFALO, NY- August 8, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 5, 2024, entitled, “Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival.”As mentioned in the Abstract of this study, overexpression of the secretory protein renalase-1 negati…

1
Dealing with Runaway Metastatic Disease 1:59

2M ago1:59

1:59

BUFFALO, NY - August 7, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on July 12, 2024, entitled, “How to deal with runaway metastatic disease?”In this new editorial, Justine Paris and Guilhem Bousquet from Université Paris Cité, Université Sorbonne Paris Nord, and APHP, Hôpital Avicenne, Oncologie médical, discussed how th…

1
INT-1B3 miR-193a-3p Mimic Boosts T Cell Immunity and Induces Tumor Cell Death 2:34

2M ago2:34

2:34

BUFFALO, NY- August 5, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 12, 2024, entitled, “INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death.”In this study, resear…

1
Sunshine and Science from #ANZUP24 on the Gold Coast 52:19

2M ago52:19

52:19

Renu and Declan escape winter in Melbourne to enjoy a few days of sunshine and science at the #ANZUP24 Annual Scientific Meeting on the Gold Coast. ANZUP is our fantastic GU Oncology co-operative trials group here in Australia and New Zealand and have an outstanding record in running clinical trials and supporting research and education in GU Oncol…

1
The Prostate Cancer Olympics 2024! With Elena Castro and Arun Azad 44:13

3M ago44:13

44:13

To celebrate the Paris 2024 Olympics, we bring you this special Olympics-themed episode of GU Cast - our very own Prostate Cancer Olympics! Yes we We are joined in the GU Cast studio by Dr Elena Castro, GU Medical Oncologist at Hospital 12 de Octubre in Madrid, who happened to be passing through Melbourne. And by our own A/Professor Arun Azad, GU M…

1
Prognostic and Therapeutic Insights Into MIF, DDT, and CD74 in Melanoma 3:32

3M ago3:32

3:32

BUFFALO, NY- July 26, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 19, 2024, entitled, “Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma.”Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression across a va…

1
Radical prostatectomy and the wave of new robots in China today 33:15

3M ago33:15

33:15

In the second of our special episodes focussing on GU Oncology in China, we are delighted to welcome back our GU Cast China Editor. Professor Yao Zhu, who has put together this cracking epsiode focussing on radical prostatectomy in China. We are joined by Professor Ming Liu (Beijing Hospital, Beijing) and Professor Jiahua Pan (Ren Ji Hospital, Shan…

1
Novel Triple-Drug Combination to Fight Pancreatic Cancer 8:10

3M ago8:10

8:10

In the ever-evolving quest for effective cancer treatments, researchers are continuously exploring innovative combinatorial approaches that exploit the vulnerabilities of malignant cells. In a new study, researchers Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, and Borje…

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Prevalence and Impact of the KIT M541L Variant in Patients with Mastocytosis 2:54

3M ago2:54

2:54

BUFFALO, NY- July 24, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 22, 2024, entitled, “Prevalence and impact of the KIT M541L variant in patients with mastocytosis.”Activating mutations in KIT, particularly D816V, have been associated with mastocytosis. Additionally, expression of heterozygous KIT M541L has been pr…

1
Oncotarget Welcomes New Editorial Board Members 1:40

3M ago1:40

1:40

BUFFALO, NY - July 22, 2024 – Oncotarget proudly welcomes new members to our esteemed Editorial Board, including our new Co-Editor-in-Chief, Dr. Wafik S. El-Deiry. Joining Dr. El-Deiry on Oncotarget’s Editorial Board are Dr. Trever Bivona, Dr. Phillip Buckhaults, Dr. Fred Bunz, Dr. Jonathan Chernoff, Dr. Stephen G. Chun, Dr. Nathan Dolloff, Dr. Pei…

1
Efficacy of Pembrolizumab with sEphB4-HSA in HPV-negative EphrinB2-positive HNSCC 3:21

3M ago3:21

3:21

BUFFALO, NY- July 22, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 10, 2024, entitled, “Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma.”Patients with relapsed or metastatic head and neck squamous cell carcinoma (HNSCC) after …

1
DDX41’s Unique Contribution to Myeloid Leukemogenesis 2:35

3M ago2:35

2:35

BUFFALO, NY- July 19, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on July 2, 2024, entitled, “DDX41 and its unique contribution to myeloid leukemogenesis.”In this new editorial, researcher Hirotaka Matsui from the National Cancer Center Hospital in Tokyo, Japan, and Kumamoto University discusses myeloid neoplasms. Until t…

1
#109 - Surgery's Complete. Now What? 28:45

3M ago28:45

28:45

This conversation is about the recovery process after prostate surgery. The speaker shares his personal experience and provides tips and advice for surviving post-surgery. He discusses waking up after surgery, the presence of a catheter, the recovery room, hospital stay, diet, bowel movements, continence, and erectile function. He emphasizes the im…

1
Using Early On-treatment ctDNA Measurements as Response Assessment in mCRPC 2:34

3M ago2:34

2:34

BUFFALO, NY- July 17, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on July 2, 2024, entitled, “Using early on-treatment circulating tumor DNA measurements as response assessment in metastatic castration resistant prostate cancer.”In this new editorial, researchers S.H. Tolmeijer, E. Boerrigter, N.P. Van Erp, and Niven Mehr…

1
We meet the Active Surveillor | Howard Wolinsky 36:08

3M ago36:08

36:08

There are patient advocates and there are patient advocates, and then there is Howard Wolinsky! We chat with the inimitable Howard, medical journalist and very long-time active surveillance patient, about his varied interests in low-risk prostate cancer and prostate cancer diagnostics. He runs a great substack called The Active Surveillor with a re…

1
HER2-low and HER2-zero in Breast Cancer Between Prognosis, Prediction and Entity 2:41

3M ago2:41

2:41

BUFFALO, NY- July 16, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on June 20, 2024, entitled, “HER2-low and HER2-zero in breast cancer between prognosis, prediction and entity.”In this new editorial, researchers Marcus Schmidt, Hans-Anton Lehr, and Katrin Almstedt from the University Medical Center of Johannes Gutenberg U…

1
Comparison of FDG-PET/CT and CT for Treatment Evaluation of Patients With Unresectable Mesothelioma 4:12

3M ago4:12

4:12

BUFFALO, NY- July 15, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Comparison of FDG-PET/CT and CT for evaluation of tumor response to nivolumab plus ipilimumab combination therapy and prognosis prediction in patients with unresectable malignant pleural mesothelioma.”Malignant pleural mesothelio…

1
AI for Improved PET/CT Attenuation Correction in Prostate Cancer Imaging 5:51

3M ago5:51

5:51

Positron Emission Tomography (PET) combined with Computed Tomography (CT) is a powerful imaging modality used in oncology for diagnosis, staging, and treatment monitoring. However, one limitation of PET/CT is the need for accurate attenuation correction (AC) to account for tissue density variations. Traditionally, low-dose CT scans are used for AC,…

1
Targeting ABC Transporters in PDAC – Past, Present, or Future? 3:00

3M ago3:00

3:00

BUFFALO, NY- July 10, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Targeting ABC transporters in PDAC – past, present, or future?”In this new editorial, Cecilia Bergonzini, Elisa Giovannetti and Erik H.J. Danen from Leiden University discuss targeting ABC transporters in pancreatic ductal carci…

1
#108 - How to Eat, Train and Prepare for Prostate Cancer Treatment 36:05

3M ago36:05

36:05

This podcast episode provides tips and advice for individuals preparing for surgery or radiation for prostate cancer or recurrence of prostate cancer. The host, a prostate cancer survivor, shares his personal experience and the strategies he used to prepare his body for these procedures. The episode covers topics such as diet, exercise, Kegel exerc…

1
#APCCC24 Conference Highlights | Part 2 1:06:10

3M ago1:06:10

1:06:10

Part 2 of our Conference Highlight specials from the Advanced Prostate Cancer Consensus Conference, held in April 2024 in Lugano. This is our very favourite prostate cancer meeting and we are thrilled to bring you these highlight podcasts. In this episode we chat with Elena Castro, Nick James, Anthony Joshua, Bertrand Tombal, Silke Gillessen, Aurel…

1
Regorafenib Synergizes With TAS102 Against Multiple Gastrointestinal Cancers 3:25

3M ago3:25

3:25

BUFFALO, NY- July 8, 2024 – A new research paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, “Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status.”Single-agent TAS1…

1
Editorial: Genomics Has More to Reveal 2:33

4M ago2:33

2:33

BUFFALO, NY- July 2, 2024 – A new editorial paper was published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Genomics has more to reveal.”In this new editorial, researchers Laurène Fenwarth and Nicolas Duployez from the University of Lille and CHU Lille discuss molecular and cytogenetic analyses that are now used to identify mutations and…

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