Episode 99 - Expectations Matter: Harnessing the Power of Placebo for Medicine

Two Brad For You

Today we delve deep into the fascinating world of the placebo effect, exploring its implications in medical treatments and the ethics surrounding its use. Dr. Helena Hartman, a neuroscientist, joins the show to talk about how expectations can significantly influence treatment outcomes. Hartman shares her research insights into pain, empathy and placebo and the importance of expectation in driving placebo effects.

We also talk about the work being done by the Treatment and Expectations group uncovering the complex interplay between expectation, treatment efficacy, and the ethical dilemmas that arise when discussing placebo in a clinical context. Hartman emphasizes the importance of transparent communication with patients regarding the use of placebos and the potential benefits they can offer when patients are informed about their effects. We also discuss the challenges posed by wellness influencers who may mislead the public into thinking that they can heal themselves through mental power alone, neglecting the necessity of real medical interventions. Hartman highlights the importance of finding a balance between promoting the benefits of medical treatments and avoiding the pitfalls of over-hyping the placebo effect, especially in the age of misinformation.

Finally we take an intriguing examination of side effects and their unexpected role in enhancing the efficacy of treatments. Hartman discusses a study showing that mild side effects from placebos can actually boost the perceived effectiveness of treatment, tying back to the central theme of expectation. This leads to a broader conversation on the implications for future medical practices, particularly in the realm of psychedelics, where the challenges of maintaining placebo control are complex.

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• Side-effects are often a curse. Can they also be a blessing?
• Accessible scientific results and exciting fictional stories in one.
• What can psychedelic drugs teach us about placebo-controlled trials?
• Treatment and Expectations Group - Find out and join in / TRR 289