Episode 12 - Single Molecule Fingerprinting Reveals Different Amplification Properties of α-synuclein Oligomers

Preprints in Motion

This week we discuss Parkinson’s Disease and single molecule spectroscopy with Dr Derrick Lau, a PostDoc at the University of New South Wales (@UNSW). Single molecular spectroscopy can be used to track the formation and purification of α-synuclein aggregates, a hallmark of PD, and potentially lead to a tool for early diagnosis of Parkinson’s Disease. We discuss how single molecular spectroscopy is transferable to medium throughput and use bio fluids for early diagnosis of Parkinson Disease but also potentially other neurodegenerative diseases. Finally, we discuss preprints, what it it like to apply for PostDocs in a pandemic as well transitioning from immunology and neuroscience.

Read the full preprint - https://www.biorxiv.org/content/10.1101/2021.08.09.455607v1.full

Other links

Microbiome in PD- https://www.nature.com/articles/s41531-021-00156-z

Immunotherapy in PD - https://pubmed.ncbi.nlm.nih.gov/31978602/

α-synuclein in PD patients biofluides - https://pubmed.ncbi.nlm.nih.gov/32444560/

AttoBright - https://www.nature.com/articles/s41467-019-13617-0

https://www.nature.com/immersive/d41586-021-02563-x/index.html

This episode was produced by Emma Wilson and edited by John D Howard .

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Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).