Democratizing Therapeutic Discovery for Neglected Diseases using AI with Timothy Jenkins of DTU Bioengineering

Data in Biotech

This week on Data in Biotech, we welcome Timothy Jenkins, the Head of Data Science and Associate Professor at DTU Bioengineering, a leading scientific community dedicated to advancing areas of biotechnology, food technology, and health through innovative teaching and research.

Timothy starts the conversation by walking us through his background and early career beginnings, from the first time he expressed interest in zoology and venomous snakes to now leading a research group focused on AI-guided drug discovery for snake antivenom.

He and our host, Ross Katz, dive into one of DTU’s most exciting recent publications about "de novo" designed proteins to neutralize lethal snake venom toxins.

Inspired by Nobel Prize winner David Baker’s groundbreaking paper and in collaboration with the Baker Lab on computational design methodology, this project holds great promise in therapeutic discovery and drug development.

Tim explains how computational protein design and protein structure prediction are revolutionizing his field, highlighting compelling examples and milestones from his research on antivenom.

He also provides an overview of the process used to discover new antivenoms, including the sourcing of biological data, model training, and integration of experimental feedback.

Finally, we get Tim’s perspective on the future of AI-powered therapeutic discovery, and his take on the integration of quantum computing into protein design.

Data in Biotech is a fortnightly podcast exploring how companies leverage data innovation in the life sciences.

Useful Links

Nature - De novo designed proteins neutralize lethal snake venom toxins

Timothy’s LinkedIn

DTU Bioengineering Website

UW Institute for Protein Design

“de novo” designed proteins project

Information on Nobel Prize winner David Baker