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There is a special subtype of neuroblastoma seen in very young children, with spread of disease throughout the body, but which needs a very different approach to treatment compared to older children with metastatic disease. This episode explains the features of this stage MS neuroblastoma, the early problems, and the treatment used. Link to Patreon…
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A few years ago I described CAR T-cells, but they weren't available for routine use. I now update things, with the very important news about CAR T-cell therapy now becoming available. There is also an interview with Dr Caroline Bateman re this subject in another episode. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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A number of countries have research studies where childhood cancers are analysed in great detail, testing all the DNA in something called 'molecular profiling'. The national Australian study of this is called PRISM, and it is a very exciting project. This episode explains a molecular profiling project and covers issues of obtaining informed consent…
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At the American Society of Clinical Oncology meeting in June 2016, a study was presented looking at using two autologous bone marrow transplants in neuroblastoma. The results were exciting.... Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Por Dr Geoff
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In this episode I read out for you an article written by Dr Susan Cohn from the University of Chicago. Dr Cohn is an eminent paediatric oncologist, and a world expert on children's cancer trials, particularly in neuroblastoma. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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When families find themselves in a hospital, they meet all sorts of doctors with all sorts of titles, residents, interns, fellows, registrars. This episode explains who's who in the childhood cancer medical team. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Por Dr Geoff
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Parents always ask why their child developed cancer. They ask if it is genetic, meaning is it something hereditary, or some abnormality in the DNA that the child was born with. In this episode I discuss a recent paper that examined this question. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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There are multiple ways to go looking for DNA, RNA and protein abnormalities. Many should still be considered research, not standard practice, but they may well be part of the future of cancer therapy. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Por Dr Geoff
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The proteins have to have the right amino acids all assembled in the right order, and the DNA code is the recipe that's used. This episode explains how the correct DNA leads to the right protein being made. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Por Dr Geoff
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To understand all this DNA analysis business, first one needs to know a bit about proteins. Proteins basically do all the work in cells, and so DNA mutations interfere with protein structures.Serious geek alert! Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Por Dr Geoff
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Platelets are tiny little cells that make blood clot properly. They go low after chemotherapy sometimes, and we often end up giving a platelet transfusion. That's one reason why blood donors save lives!This episode explains all about platelet transfusions. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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Clinical trials are core business in childhood cancer units. It is through clinical trials that we have worked out what treatments are effective, and future trials will lead to further gains. This episode describes what a clinical trial is, and introduces some of the key concepts. Link to Patreon Hosted on Acast. See acast.com/privacy for more info…
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