Interviews with authors of JAMA Guide to Statistics and Methods chapters about common and new statistics and methods used in clinical research and reported in medical journals.
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JAMA editors and authors explain the methods underlying clinical research to help students, trainees, and health professionals use the published medical literature to make evidence-based decisions for patients. JAMAevidence is an evidence-based medicine (EBM) resource created and maintained by the JAMA Network to promote the use of EBM to improve patient care.
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Interviews with authors of Rational Clinical Examination systematic reviews in JAMA about the accuracy of the medical history, physical examination, and laboratory testing for the diagnosis of common medical conditions. JAMAevidence is an evidence-based medicine (EBM) resource created and maintained by JAMA Network to promote the use of EBM to improve patient care.
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Interviews with authors of Care at the Close of Life reviews in JAMA about management issues in end of life and palliative care. JAMAevidence is an evidence-based medicine (EBM) resource created and maintained by the JAMA Network to promote the use of EBM to improve patient care.
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William J. Meurer, MD, MS, University of Michigan Medical School, discusses Interim Analyses During Group Sequential Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Interim Analyses During Group Sequential Clinical Trials
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Mark C. Wilson MD, MPH, University of Iowa, discusses Teachers’ Guides to the Users’ Guides with Gordon H. Guyatt, MD, MSc, McMaster University. Related Content: Evidence vs Consensus in Clinical Practice Guidelines How to Interpret and Use a Clinical Practice Guideline or Recommendation
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Jerome I. Rotter, MD, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center, discusses Genome-Wide Association Studies with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Genome-Wide Association Studies…
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Benjamin R. Saville, PhD, president and lead statistical scientist of Adaptix Trials, LLC and adjoint associate professor of biostatistics at Vanderbilt University Medical Center, discusses Conditional Power: How Likely Is Trial Success? with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Conditional Power…
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Anna E. McGlothlin, PhD, Berry Consultants, LLC, discusses Bayesian Hierarchical Models with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Bayesian Hierarchical Models
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Kelley Kidwell, PhD, professor of biostatistics, University of Michigan, discusses Sequential, Multiple Assignment, Randomized Trial Designs with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Sequential, Multiple Assignment, Randomized Trial Designs
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Dislocated hips in newborns can lead to complex surgery, interruption to family life, and premature osteoarthritis. Daniel Perry, MBChb(Hons), PhD, of Alder Hey Children's Hospital, University of Liverpool, discusses the clinical diagnosis of dislocated hips in newborns with JAMA Associate Editor David Simel, MD, MHS. Related Content: Does This Inf…
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Miguel A. Hernán, MD, DrPH, professor of epidemiology, Harvard T.H. Chan School of Public Health, discusses Target Trial Emulation: A Framework for Causal Inference From Observational Data with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Target Trial Emulation
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses On Deep Learning for Medical Image Analysis with Lawrence Carin, PhD. Related Content: On Deep Learning for Medical Image Analysis
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Patient-Reported Outcome Measures in Clinical Research with Kevin P. Weinfurt, PhD, and Bryce B. Reeve, PhD. Related Content: Patient-Reported Outcome Measures in Clinical Research
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JAMA Associate Editor David L. Simel, MD, MHS, discusses Does This Child With High Blood Pressure Have Secondary Hypertension? with James T. Nugent, MD, MPH. Related Content: Does This Child With High Blood Pressure Have Secondary Hypertension?
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Immortal Time Bias in Observational Studies with Kabir Yadav, MDCM, MS, MSHS. Related Content: Immortal Time Bias in Observational Studies
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Adjustment for Baseline Characteristics in Randomized Clinical Trial with Lars W. Andersen, MD, MPH, PhD, DMSc. Related Content: Adjustment for Baseline Characteristics in Randomized Clinical Trials
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Odds Ratios—Current Best Practice and Use with Edward C. Norton, PhD. Related Content: Odds Ratios—Current Best Practice and Use Types and Distribution of Payments From Industry to Physicians in 2015
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Gordon H. Guyatt, MD, MSc, discusses Assessing the Strength of Recommendations: The GRADE Approach with Per Olav Vandvik, MD, PhD. Related Content: How to Interpret and Use a Clinical Practice Guideline or Recommendation
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Host Gordon Guyatt, MD, MSc, discusses Understanding and Applying the Results of a Systematic Review with M. Hassan Murad, MD, MPH. Related Content: How to Read a Systematic Review and Meta-analysis and Apply the Results to Patient Care Acute Treatments for Episodic Migraine in Adults
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Roger J. Lewis, MD, PhD, discusses Estimands, Estimators, and Estimates with Roderick J. Little, PhD, in the JAMA Guide to Statistics and Methods series. Related Content: Estimands, Estimators, and Estimates
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Gordon H. Guyatt, MD, MSc, discusses Fixed-Effects and Random-Effects Models with M. Hassan Murad, MD. Related Content: Random-Effects Meta-analysis
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Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection? With Dr Johnson
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David L. Simel, MD, discusses Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection? with Davin Johnson, MD. Related Content: Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection?
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Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses With Dr Smith
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Roger J. Lewis, MD, PhD, discusses Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses with Valerie A. Smith, DrPH. Related Content: Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Time-to-Event Analysis with Juliana Tolles, MD, MHS. Related Content: Time-to-Event Analysis
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Gordon H. Guyatt, MD, MSc, discusses Adjusted Analyses in Studies Addressing Therapy and Harm with Thomas Agoritsas, MD, PhD. Related Content: Adjusted Analyses in Studies Addressing Therapy and Harm
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Adjusting for Nonadherence or Stopping Treatments with Amanda I. Adler, MD, PhD, and Nicholas Latimer, PhD. Related Content: Adjusting for Nonadherence or Stopping Treatments in Randomized Clinical Trials
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Gordon Guyatt, MD, MSc, discusses Spectrum Bias with Reem A. Mustafa. MD, MPH, PhD.
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Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data With Dr Lachin
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JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data with John M. Lachin, ScD. Related Content: Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data
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Gordon Guyatt, MD, MSc, discusses Discrimination and Calibration of Clinical Prediction Models with Ana Carolina Alba, MD, PhD. Related Content: Discrimination and Calibration of Clinical Prediction Models With Dr Alba Read Transcript
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Using Latent Class Analysis to Identify Hidden Clinical Phenotypes With Dr Heather G. Allore
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JAMA Statistical Editor Roger Lewis, MD, PhD, discusses Using Latent Class Analysis to Identify Hidden Clinical Phenotypes with Heather G. Allore, PhD. Related Content:
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How to Interpret and Use a Clinical Practice Guideline or Recommendation With Dr Gordon Guyatt and Dr Brignardello-Petersen
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Host Robert M. Golub, MD, discusses How to Interpret and Use a Clinical Practice Guideline or Recommendation with Gordon H. Guyatt, MD, MSc, and Romina Brignardello-Petersen, DDS, MSc, PhD.
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Gordon Guyatt, MD, discusses Measuring Agreement Beyond Chance with Thomas McGinn, MD, MPH. Related Content: Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review
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JAMA Statistical Editor Roger Lewis, MD, PhD, discusses Use of Run-in Periods in Randomized Trials with Jane M. Armitage, MBBS. Related Content: Use of Run-in Periods in Randomized Trials With Dr Armitage Short- and Long-term Effects of a Mobile Phone App in Conjunction With Brief In-Person Counseling on Physical Activity Among Physically Inactive …
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Regression Discontinuity Study Design to Estimate Observational Differences With Dr Maciejewski
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JAMA Statistical Editor Roger Lewis, MD, discusses Regression Discontinuity Design with Matthew L. Maciejewski, PhD. Related Content: Regression Discontinuity Design Using Instrumental Variables to Address Bias From Unobserved Confounders
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Gordon H. Guyatt, MD, MSc, discusses
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David Simel, MD, discusses Does This Patient Have Hypertension? with Anthony J. Viera, MD, MPH. Related Content: Does This Adult Patient Have Hypertension? Interview With Dr Anthony Joseph Viera USPSTF Recommendation: Screening for Hypertension in Adults USPSTF Review: Screening for Hypertension in Adults…
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JAMA Statistical Editor Roger Lewis, MD, discusses Case-Control Studies: Using “Real-world” Evidence to Assess Association, With Dr Irony.
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Gordon Guyatt, MD, discusses economic analysis with Paul Moayyedi, PhD
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Roger J. Lewis, MD, PhD, discusses Equipoise in Research—Integrating Ethics and Science in Human Research with Alex John London, PhD Related Content: Equipoise in Research—Integrating Ethics and Science in Human Research
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Roger J. Lewis, MD, PhD, discusses Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Melanie Quintana, PhD Related Content: Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among New…
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Cost-effectiveness analysis defines trade-offs between costs, harms, and benefits of alternative treatments and combines them into a single metric, the incremental cost-effectiveness ratio (ICER), that can inform decisions about which interventions to recommend when limited resources are available. Gillian Sanders-Schmidler, PhD, professor of popul…
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Gordon Guyatt, MD, discusses Misleading Presentations of Clinical Trial Results with Victor Montori, MD Related Content: Misleading Presentations of Clinical Trial Results with Dr Victor Montori When Can Intermediate Outcomes Be Used in Clinical Trials? When Guidelines Recommend Shared Decision-making…
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David Simel, MD, discusses Does This Patient Have Hip Osteoarthritis? with David Metcalfe, PhD, MRCP, MRCS, MRCEM
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Anne M. Holbrook, MD and Gordon Guyatt, MD, discuss Surrogate Outcomes from the JAMA Users’ Guides to the Medical Literature Related Content: When Can Intermediate Outcomes Be Used as Surrogate Outcomes? FDA Acceptance of Surrogate End Points for Cancer Drug Approval: 1992-2019 What Constitutes a Valid Surrogate End Point in Cancer Clinical Trials?…
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JAMA Deputy Editor Edward Livingston, MD, discusses "Multiple Comparison Procedures" with Dr. Jing Cao, PhD
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David Simel, MD, discusses Did This Patient Have Cardiac Syncope? with Edward Etchells, MD, MSc
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Logistic regression is one of the most commonly used statistical analytic tools in the medical literature. William Meurer, MD, from the University of Michigan, and Juliana Tolles, MD, from UCLA, discuss a JAMA Guide to Statistics and Methods article they wrote entitled “Logistic Regression Diagnostics: Understanding How Well a Model Predicts Outcom…
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Roger J. Lewis, MD, PhD, discusses Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods Related Article(s): Randomization in Clinical Trials
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Interview with Yun Liu, author of How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature
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Dr David Simel discusses Will This Patient Be Difficult to Intubate? with Dr Michael Detsky
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Cluster randomized trials are performed when an intervention must be delivered to a group of patients like when testing new nursing protocols on award or different means for cleaning beds on a ward. One type of cluster trials is called a stepped-wedge where every cluster in the study ultimately undergoes the intervention. How this works it is expla…
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JAMA Deputy Editor Edward Livingston, MD, discusses Minimal Clinically Important Difference: Defining What Really Matters to Patients with Anna E. McGlothlin, PhD
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One of the most common causes for problems we see in manuscripts at JAMA is an inappropriately calculated study sample size. This seemingly mysterious process is explained by Lynne Stokes, PhD, professor of Statistical Science at Southern Methodist University in Dallas, Texas.
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